Article
Loss of exosomes in progranulin-associated frontotemporal dementia.
Neurobiology of aging - 1 Apr 2016
Benussi Luisa, Ciani Miriam, Tonoli Elisa, Morbin Michela, Palamara Luisa, Albani Diego, Fusco Federica, Forloni Gianluigi, Glionna Michela, Baco Monika, Paterlini Anna, Fostinelli Silvia, Santini Benedetta, Galbiati Elisabetta, Gagni Paola, Cretich Marina, Binetti Giuliano, Tagliavini Fabrizio, Prosperi Davide, Chiari Marcella, Ghidoni Roberta
Abstract excerpt
Many cells of the nervous system have been shown to release exosomes, a subclass of secreted vesicles of endosomal origin capable of transferring biomolecules among cells: this transfer modality represents a novel physiological form of intercellular communication between neural cells. Herein, we demonstrated that progranulin (PGRN), a protein targeted to the classical secretory pathway, is also secreted in...
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