Article
Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer.
The Journal of molecular diagnostics : JMD - 1 May 2016
Wang Sophie R, Malik Simeen, Tan Iain B, Chan Yang Sun, Hoi Qiangze, Ow Jack L, He Cassandra Z, Ching Cindy E, Poh Dianne Y S, Seah Hui Maan, Cheung Katie H T, Perumal Dharuman, Devasia Arun G, Pan Lu, Ang Shimin, Lee Seow Eng, Ten Rachel, Chua Clarinda, Tan Daniel S W, Qu James Z Z, Bylstra Yasmin M, Lim Lionel, Lezhava Alexander, Ng Pauline C, Wong Christopher W, Lim Tony, Tan Patrick
Abstract excerpt
Targeted next-generation sequencing is becoming increasingly common as a clinical diagnostic and prognostic test for patient- and tumor-specific genetic profiles as well as to optimally select targeted therapies. Here, we describe a custom-developed, next-generation sequencing test for detecting single-nucleotide variants (SNVs) and short insertions and deletions (indels) in 93 genes related to gastrointestinal...
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