Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.

doi:10.1016/j.jmoldx.2015.11.006

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Article

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.

The Journal of molecular diagnostics : JMD - 1 Mar 2016

Fisher Kevin E, Zhang Linsheng, Wang Jason, Smith Geoffrey H, Newman Scott, Schneider Thomas M, Pillai Rathi N, Kudchadkar Ragini R, Owonikoko Taofeek K, Ramalingam Suresh S, Lawson David H, Delman Keith A, El-Rayes Bassel F, Wilson Malania M, Sullivan H Clifford, Morrison Annie S, Balci Serdar, Adsay N Volkan, Gal Anthony A, Sica Gabriel L, Saxe Debra F, Mann Karen P, Hill Charles E, Khuri Fadlo R, Rossi Michael R

Abstract excerpt

We tested and clinically validated a targeted next-generation sequencing (NGS) mutation panel using 80 formalin-fixed, paraffin-embedded (FFPE) tumor samples. Forty non-small cell lung carcinoma (NSCLC), 30 melanoma, and 30 gastrointestinal (12 colonic, 10 gastric, and 8 pancreatic adenocarcinoma) FFPE samples were selected from laboratory archives. After appropriate specimen and nucleic acid quality control, 80...

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PMID: 26801070
DOI: 10.1016/j.jmoldx.2015.11.006
PMCID: PMC4816706

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BRAF

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