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SF3B1-mutated myelodysplastic syndrome with ring sideroblasts harbors more severe iron overload and corresponding over-erythropoiesis.

Leukemia research - 1 May 2016

Zhu Yang, Li Xiao, Chang Chunkang, Xu Feng, He Qi, Guo Juan, Tao Ying, Liu Yizhi, Liu Li, Shi Wenhui

Abstract excerpt

OBJECTIVE: To clarify the possible biological differences and implication of the SF3B1 gene for patients with MDS-RS (myelodysplastic syndromes with ring sideroblasts). METHODS: Sanger sequencing was performed on mutation hotspots of the SF3B1 gene in MDS-RS patients. The differences between the SF3B1 mutated and wild-type subsets, including the ultrastructure of erythroid precursors, iron profile parameters,...

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Identifiers

PMID: 26970172
DOI: 10.1016/j.leukres.2016.02.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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