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Article

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern.

Blood advances - 22 Oct 2019

Berger Gerbrig, Gerritsen Mylene, Yi Guoqiang, Koorenhof-Scheele Theresia N, Kroeze Leonie I, Stevens-Kroef Marian, Yoshida Kenichi, Shiraishi Yuichi, van den Berg Eva, Schepers Hein, Huls Geert, Mulder André B, Ogawa Seishi, Martens Joost H A, Jansen Joop H, Vellenga Edo

Abstract excerpt

Ring sideroblasts (RS) emerge as result of aberrant erythroid differentiation leading to excessive mitochondrial iron accumulation, a characteristic feature for myelodysplastic syndromes (MDS) with mutations in the spliceosome gene SF3B1. However, RS can also be observed in patients diagnosed with acute myeloid leukemia (AML). The objective of this study was to characterize RS in patients with AML. Clinically,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

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Identifiers

PMID: 31648334
DOI: 10.1182/bloodadvances.2019000518
PMCID: PMC6849935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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