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Article

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome.

Scientific reports - 26 Aug 2022

Ochi Tetsuro, Fujiwara Tohru, Ono Koya, Suzuki Chie, Nikaido Maika, Inoue Daichi, Kato Hiroki, Onodera Koichi, Ichikawa Satoshi, Fukuhara Noriko, Onishi Yasushi, Yokoyama Hisayuki, Nakamura Yukio, Harigae Hideo

Abstract excerpt

Acquired sideroblastic anemia, characterized by bone marrow ring sideroblasts (RS), is predominantly associated with myelodysplastic syndrome (MDS). Although somatic mutations in splicing factor 3b subunit 1 (SF3B1), which is involved in the RNA splicing machinery, are frequently found in MDS-RS, the detailed mechanism contributing to RS formation is unknown. To explore the mechanism, we established human...

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Identifiers

PMID: 36028755
DOI: 10.1038/s41598-022-18921-2
PMCID: PMC9418223

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