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Article

Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.

Human molecular genetics - 1 Nov 2011

Cheng Hong, Khan Naheed W, Roger Jerome E, Swaroop Anand

Abstract excerpt

The orphan nuclear receptor NR2E3 is a direct transcriptional target of NRL, the key basic motif leucine zipper transcription factor that dictates rod versus cone photoreceptor cell fate in the mammalian retina. The lack of NR2E3 function in humans and in retinal degeneration rd7 mutant mouse leads to increased S-cones accompanied by rod degeneration, whereas ectopic expression of Nr2e3 in the cone-only Nrl(-/-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21813656
DOI: 10.1093/hmg/ddr334
PMCID: PMC3188990

Genes

NRL

Provenance

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Related research

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Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.PMID 21813656Read ↗

Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseasesSemantic proximity Read ↗

Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3): Role in Retinal Development and DiseaseSemantic proximity Read ↗

Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.Semantic proximity Read ↗

The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.Semantic proximity Read ↗

Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome.Semantic proximity Read ↗

Expression of Photoreceptor-Specific Nuclear Receptor NR2E3 in Rod Photoreceptors of Fetal Human RetinaSemantic proximity Read ↗

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal developmentSemantic proximity Read ↗

Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal developmentSemantic proximity Read ↗

Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.Semantic proximity Read ↗

A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone SyndromeSemantic proximity Read ↗

Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-Only<i>Nrl</i><sup>−/−</sup>Mouse RetinaSemantic proximity Read ↗

Nrl expression and promoter activity in developing cone photoreceptorsSemantic proximity Read ↗

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