Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.

Oncotarget - 19 Apr 2016

Gomez-Roman Natividad, Sahasrabudhe Neha Mohan, McGregor Fiona, Chalmers Anthony J, Cassidy Jim, Plumb Jane

Abstract excerpt

The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments. This type of migration has been shown to require the expression of the hypoxia-inducible factor 1 alpha (HIF-1α). In this report we demonstrate that Rab25 regulates HIF-1α protein expression in an oxygen independent manner in a panel of cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ovarian Epithelial
Share to Heterografts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mice, Nude

Share to Neoplasm Invasiveness

Share to Neoplasms, Glandular and Epithelial

Share to Ovarian Neoplasms

Share to rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26967059
DOI: 10.18632/oncotarget.7998
PMCID: PMC5008389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.PMID 26967059Read ↗

Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinomaSemantic proximity Read ↗

ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancerSemantic proximity Read ↗

Knockdown of hypoxia-inducible factor-1 alpha reduces proliferation, induces apoptosis and attenuates the aggressive phenotype of retinoblastoma WERI-Rb-1 cells under hypoxic conditions.Semantic proximity Read ↗

Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.Semantic proximity Read ↗

AMPK-independent LKB1 activity is required for efficient epithelial ovarian cancer metastasisSemantic proximity Read ↗

Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycinSemantic proximity Read ↗

hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic processSemantic proximity Read ↗

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasionSemantic proximity Read ↗

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cellsSemantic proximity Read ↗

Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasisSemantic proximity Read ↗

Loss of RAB25 expression in breast cancer.Semantic proximity Read ↗

Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.