Article
Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.
BioMed research international - 1 Jan 2024
Joshi Pooja, Ayyagari Vijayalakshmi, Kandel Samikshya, Modur Vishnu, Iqbal Muhammad F, Robinson Kathy, Gao John, Rao Krishna
Abstract excerpt
The loss of RAB25 expression-RAS superfamily of GTPase characteristic of numerous breast cancers-corresponds with H-RAS point mutations, particularly in triple-negative breast cancers (TNBC), a subtype associated with a poor prognosis. To address the poorly understood factors dictating the progression of TNBC tumors, we examine the cooperative effects that loss of RAB25 expression in human mammary epithelial cell...
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