Article
FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data.
BMC bioinformatics - 9 Mar 2016
Li Yafang, Byun Jinyoung, Cai Guoshuai, Xiao Xiangjun, Han Younghun, Cornelis Olivier, Dinulos James E, Dennis Joe, Easton Douglas, Gorlov Ivan, Seldin Michael F, Amos Christopher I
Abstract excerpt
BACKGROUND: Identifying subpopulations within a study and inferring intercontinental ancestry of the samples are important steps in genome wide association studies. Two software packages are widely used in analysis of substructure: Structure and Eigenstrat. Structure assigns each individual to a population by using a Bayesian method with multiple tuning parameters. It requires considerable computational time when...
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