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Article

Genotypes of informative loci from 1000 Genomes data allude evolution and mixing of human populations.

Scientific reports - 7 Sept 2021

Padakanti Sridevi, Tiong Khong-Loon, Chen Yan-Bin, Yeang Chen-Hsiang

Abstract excerpt

Principal Component Analysis (PCA) projects high-dimensional genotype data into a few components that discern populations. Ancestry Informative Markers (AIMs) are a small subset of SNPs capable of distinguishing populations. We integrate these two approaches by proposing an algorithm to identify necessary informative loci whose removal from the data deteriorates the PCA structure. Unlike classical AIMs, necessary...

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Identifiers

PMID: 34493766
DOI: 10.1038/s41598-021-97129-2
PMCID: PMC8423758

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