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Article

Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes.

Familial cancer - 1 Jul 2016

Lindor Noralane M, Hopper John, Dowty James

Abstract excerpt

The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family...

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PMID: 26960971
DOI: 10.1007/s10689-016-9896-2
PMCID: PMC4901094

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