Article
Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF (V600E) Harboring Pediatric Papillary Thyroid Carcinomas.
Endocrine pathology - 1 Jun 2016
Onder Semen, Ozturk Sari Sule, Yegen Gulcin, Sormaz Ismail Cem, Yilmaz Ismail, Poyrazoglu Sukran, Sanlı Yasemin, Giles Senyurek Yasemin, Kapran Yersu, Mete Ozgur
Abstract excerpt
This study is aimed to investigate the BRAF (V600E) and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6-18). No TERT promoter mutations were identified in this series. The BRAF (V600E) mutation was present in 15 (30 %) tumors. From genotype-histologic variant correlation...
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