Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue.

Epigenetics - 1 Jan 2016

Etzold Anna, Galetzka Danuta, Weis Eva, Bartsch Oliver, Haaf Thomas, Spix Claudia, Itzel Timo, Schweiger Susann, Strand Dennis, Strand Susanne, Zechner Ulrich

Abstract excerpt

Constitutive epimutations of tumor suppressor genes are increasingly considered as cancer predisposing factors equally to sequence mutations. In light of the emerging role of the microenvironment for cancer predisposition, initiation, and progression, we aimed to characterize the consequences of a BRCA1 epimutation in cells of mesenchymal origin. We performed a comprehensive molecular and cellular comparison of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Genes, Homeobox

Share to Genes, Tumor Suppressor

Share to Haploinsufficiency

Share to Neoplasm Recurrence, Local

Source

Open in PubMed Open full text

Identifiers

PMID: 26949839
DOI: 10.1080/15592294.2016.1140295
PMCID: PMC4846144

Genes

BRCA1
ACTA2
FAP
PDPN
TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue.PMID 26949839Read ↗

Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinomaSemantic proximity Read ↗

Single-cell transcriptome analysis reveals evolutionarily conserved features during the transition from normal breast stromal cells to cancer-associated fibroblastsSemantic proximity Read ↗

Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophagesSemantic proximity Read ↗

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesisSemantic proximity Read ↗

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencingSemantic proximity Read ↗

TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosisSemantic proximity Read ↗

[Advancement of phenotype transformation of cancer-associated fibroblasts: from genetic alterations to epigenetic modification].Semantic proximity Read ↗

Genomic analysis of atypical fibroxanthoma.Semantic proximity Read ↗

Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.Semantic proximity Read ↗

Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseasesSemantic proximity Read ↗

Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis BullosaSemantic proximity Read ↗

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like TendenciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.