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Article

GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer.

Genetics research - 20 May 2015

Laitman Yael, Jaeger Emma, Katz Lior, Tomlinson Ian, Friedman Eitan

Abstract excerpt

BACKGROUND: A 40 kb ancestral germline duplication upstream of the GREM1 gene was reported in Ashkenazi families with hereditary mixed polyposis syndrome (HMPS). OBJECTIVE: Assess the contribution of the GREM1 mutation to familial colorectal cancer (CRC) in Ashkenazim. METHODS: Jewish Ashkenazi individuals (n = 472 155 males, 317 females) were genotyped for the GREM1 duplication, 194 with CRC, 131 had other...

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Source

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Identifiers

PMID: 25992589
DOI: 10.1017/S0016672315000105
PMCID: PMC4745135

Genes

GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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