Article
GREM1 and POLE variants in hereditary colorectal cancer syndromes.
Genes, chromosomes & cancer - 1 Jan 2016
Rohlin Anna, Eiengård Frida, Lundstam Ulf, Zagoras Theofanis, Nilsson Staffan, Edsjö Anders, Pedersen Jan, Svensson Janhenry, Skullman Stefan, Karlsson B Göran, Björk Jan, Nordling Margareta
Abstract excerpt
Hereditary factors are thought to play a role in at least one third of patients with colorectal cancer (CRC) but only a limited proportion of these have mutations in known high-penetrant genes. In a relatively large part of patients with a few or multiple colorectal polyps the underlying genetic cause of the disease is still unknown. Using exome sequencing in combination with linkage analyses together with...
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