Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.

doi:10.2337/db15-1533

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Article

Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.

Diabetes - 1 Jun 2016

Xu Min, Huang Ya, Xie Lan, Peng Kui, Ding Lin, Lin Lin, Wang Po, Hao Mingli, Chen Yuhong, Sun Yimin, Qi Lu, Wang Weiqing, Ning Guang, Bi Yufang

Abstract excerpt

We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011-2013. We genotyped 34 T2D-associated common variants identified in East Asians and created a genetic risk score (GRS). We assessed arterial stiffness noninvasively with the...

Topics

Adult
Aged
Ankle Brachial Index
Asian People
China
Diabetes Mellitus, Type 2
Female
Genetic Predisposition to Disease
Genotype
Humans
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin Resistance

Insulin Secretion

Male

Mendelian Randomization Analysis

Middle Aged

Odds Ratio

Pulse Wave Analysis

Source

Open in PubMed

Identifiers

PMID: 26953161
DOI: 10.2337/db15-1533

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