Article
Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.
Environmental health perspectives - 1 Jul 2016
Alkaissi Hammoudi, Ekstrand Jimmy, Jawad Aksa, Nielsen Jesper Bo, Havarinasab Said, Soderkvist Peter, Hultman Per
Abstract excerpt
BACKGROUND: Following human mercury (Hg) exposure, the metal accumulates in considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg have been studied extensively, factors responsible for interindividual variation in humans are largely unknown. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic interstrain variation regulating retention or/and...
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