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Article

ALDH2 Glu504Lys Confers Susceptibility to Schizophrenia and Impacts Hippocampal-Prefrontal Functional Connectivity.

Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2017

Zheng Fanfan, Yan Hao, Liu Bing, Yue Weihua, Fan Lingzhong, Liao Jinmin, Cui Yue, Lu Tianlan, Jiang Tianzi, Zhang Dai

Abstract excerpt

Although previous evidence suggested that ALDH2 is a candidate gene for schizophrenia, the association and underlying mechanisms have never been investigated. Therefore, we investigated ALDH2 as a susceptibility gene for schizophrenia and explored the effect of its polymorphisms on brain functions. In the discovery stage, we detected a positive association between a dominant-negative mutant, Glu504Lys, and...

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Source

Identifiers

PMID: 26941382
DOI: 10.1093/cercor/bhw056

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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