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Article

Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72.

Current pharmaceutical design - 1 Jan 2012

Mechelli Andrea, Fusar-Poli Paolo, Prata Diana, Papagni Sergio Alessandro, Tognin Stefania, Kambeitz Joseph, Fu Cynthia, Picchioni Marco, Walshe Muriel, Toulopoulou Timothea, Bramon Elvira, Murray Robin, McGuire Philip

Abstract excerpt

Recent studies have described G72 and DAAO as susceptibility genes for schizophrenia and bipolar disorder. Both genes modulate glutamate neurotransmission, which plays a key role in neurocognitive function and is thought to be altered in these disorders. Moreover, in vitro transcription studies indicate that the two genes interact with each other at the molecular level. However, it is unclear how these genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22239582
DOI: 10.2174/138161212799316037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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