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Article

Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction.

Journal of hepatology - 1 Jun 2016

Shi Xiao-Lei, Mancham Shanta, Hansen Bettina E, de Knegt Robert J, de Jonge Jeroen, van der Laan Luc J W, Rivadeneira Fernando, Metselaar Herold J, Kwekkeboom Jaap

Abstract excerpt

BACKGROUND & AIMS: Co-inhibitory receptor-ligand interactions fine-tune immune responses by negatively regulating T cell functions. Our aim is to examine the involvement of co-inhibitory receptor-ligand pair PD-1/PD-L1 in regulating rejection after liver transplantation (LT) in humans. METHODS: PD-L1/PD-1 expression in liver allograft was determined by immunohistochemistry or flow cytometry, and the effect of...

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Identifiers

PMID: 26941095
DOI: 10.1016/j.jhep.2016.02.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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