Article
Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.
Stroke - 1 Mar 2022
Hu Yao, Haessler Jeffrey W, Manansala Regina, Wiggins Kerri L, Moscati Arden, Beiser Alexa, Heard-Costa Nancy L, Sarnowski Chloe, Raffield Laura M, Chung Jaeyoon, Marini Sandro, Anderson Christopher D, Rosand Jonathan, Xu Huichun, Sun Xiao, Kelly Tanika N, Wong Quenna, Lange Leslie A, Rotter Jerome I, Correa Adolfo, Vasan Ramachandran S, Seshadri Sudha, Rich Stephen S, Do Ron, Loos Ruth J F, Longstreth William T, Bis Joshua C, Psaty Bruce M, Tirschwell David L, Assimes Themistocles L, Silver Brian, Liu Simin, Jackson Rebecca, Wassertheil-Smoller Sylvia, Mitchell Braxton D, Fornage Myriam, Auer Paul L, Reiner Alex P, Kooperberg Charles
Abstract excerpt
BACKGROUND AND PURPOSE: Stroke is the leading cause of death and long-term disability worldwide. Previous genome-wide association studies identified 51 loci associated with stroke (mostly ischemic) and its subtypes among predominantly European populations. Using whole-genome sequencing in ancestrally diverse populations from the Trans-Omics for Precision Medicine (TOPMed) Program, we aimed to identify novel...
Topics
Join the communities discussing this publication.