Article
Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia.
Journal of leukocyte biology - 1 Jun 2016
Jost Tanja Rezzonico, Borga Chiara, Radaelli Enrico, Romagnani Andrea, Perruzza Lisa, Omodho Lorna, Cazzaniga Giovanni, Biondi Andrea, Indraccolo Stefano, Thelen Marcus, Te Kronnie Geertruy, Grassi Fabio
Abstract excerpt
Infiltration of the central nervous system is a severe trait of T cell acute lymphoblastic leukemia. Inhibition of CXC chemokine receptor 4 significantly ameliorates T cell acute lymphoblastic leukemia in murine models of the disease; however, signaling by CXC chemokine receptor 4 is important in limiting the divagation of peripheral blood mononuclear cells out of the perivascular space into the central nervous...
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