Article
Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor
27 May 2017
Abstract excerpt
). Although cellular viability, growth, proliferation, and survival of ALL cells were found to be independent of VEGF, transendothelial migration through CNS microvascular endothelial cells was regulated by VEGF. The importance of VEGF produced by ALL cells in mediating leukemia-cell entry into the CNS and leptomeningeal infiltration was further demonstrated by specific reduction of CNS leukemia on in vivo VEGF...
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