Article
Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2005
Stein Torsten, Price Karen N, Morris Joanna S, Heath Victoria J, Ferrier Roderick K, Bell Alexandra K, Pringle Marie-Anne, Villadsen René, Petersen Ole W, Sauter Guido, Bryson Gareth, Mallon Elizabeth A, Gusterson Barry A
Abstract excerpt
PURPOSE: Microarray studies have linked Annexin A8 RNA expression to a "basal cell-like" subset of breast cancers, including BRCA1-related cancers, that are characterized by cytokeratin 5 (CK5) and CK17 expression and show poor prognosis. We assessed Annexin A8's contribution to the overall prognosis and its expression in normal, benign, and cancerous tissue and addressed Annexin A8's physiologic role in the...
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