Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survival according to BRAF-V600 tumor mutations--an analysis of 437 patients with primary melanoma.

PloS one - 1 Jan 2014

Meckbach Diana, Bauer Jürgen, Pflugfelder Annette, Meier Friedegund, Busch Christian, Eigentler Thomas K, Capper David, von Deimling Andreas, Mittelbronn Michel, Perner Sven, Ikenberg Kristian, Hantschke Markus, Büttner Petra, Garbe Claus, Weide Benjamin

Abstract excerpt

The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Cutaneous Malignant

Share to Neoplasm Staging

Share to Prognosis

Share to Proto-Oncogene Proteins B-raf

Share to Registries

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24475086
DOI: 10.1371/journal.pone.0086194
PMCID: PMC3901680

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival according to BRAF-V600 tumor mutations--an analysis of 437 patients with primary melanoma.PMID 24475086Read ↗

Prognostic value of BRAF(V⁶⁰⁰) mutations in melanoma patients after resection of metastatic lymph nodes.Semantic proximity Read ↗

Association of BRAF Mutation Status with Histopathological Characteristics and Survival Outcomes in Stage II-III Malignant Melanoma.Semantic proximity Read ↗

The Impact of BRAF Mutational Status on Survival in Melanoma Patients: Single Centre Experience.Semantic proximity Read ↗

BRAF mutational status as a prognostic marker for survival in malignant melanoma: a systematic review and meta-analysis.Semantic proximity Read ↗

Is BRAF a prognostic factor in stage III skin melanoma? A retrospective study of 72 patients after positive sentinel lymph node dissection.Semantic proximity Read ↗

BRAF V600E mutation as a prognostic factor in cutaneous melanoma patients.Semantic proximity Read ↗

Prognostic value of BRAF mutations in localized cutaneous melanoma.Semantic proximity Read ↗

Nationwide Outcomes of Advanced Melanoma According to BRAFV600 Status.Semantic proximity Read ↗

Population-based analysis of the prevalence of BRAF mutation in patients diagnosed with cutaneous melanoma and its significance as a prognostic factor.Semantic proximity Read ↗

Disease progression and patient survival are significantly influenced by BRAF protein expression in primary melanoma.Semantic proximity Read ↗

BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival.Semantic proximity Read ↗

The role of BRAF mutations in primary melanoma growth rate and survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.