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Article

DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR

25 Feb 2016

Abstract excerpt

DNA methyltransferase DNMT3B is frequently overexpressed in tumor cells and plays important roles during the formation and progression of several cancer types. However, the specific signaling pathways controlled by DNMT3B in cancers, including melanoma, are poorly understood. Here, we report that DNMT3B plays a pro-tumorigenic role in human melanoma and that DNMT3B loss dramatically suppresses melanoma formation...

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PMID: 26923591
DOI: 10.1016/j.celrep.2016.02.010

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