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Article

RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling.

The American journal of pathology - 1 Feb 2021

Sarma Ashapurna, Gajan Ambikai, Kim Seongho, Gurdziel Katherine, Mao Guangzhao, Nangia-Makker Pratima, Shekhar Malathy P V

Abstract excerpt

Canonical Wnt signaling is critical for melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme critical for translesion DNA synthesis, potentiates β-catenin stability/activity by inducing proteasome-insensitive polyubiquitination. RAD6B expression is induced by β-catenin, triggering a positive feedback loop between the two proteins. RAD6B function in melanoma...

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Source

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Identifiers

PMID: 33181138
DOI: 10.1016/j.ajpath.2020.10.015
PMCID: PMC7888193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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