Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of TSC1 mutation spectrum in mucosal melanoma.

Journal of cancer research and clinical oncology - 1 Feb 2018

Ma Meng, Dai Jie, Xu Tianxiao, Yu Sifan, Yu Huan, Tang Huan, Yan Junya, Wu Xiaowen, Yu Jiayi, Chi Zhihong, Si Lu, Cui Chuanliang, Sheng Xinan, Kong Yan, Guo Jun

Abstract excerpt

PURPOSE: Mucosal melanoma is a relatively rare subtype of melanoma for which no clearly established therapeutic strategy exists. The genes of the mTOR signalling pathway have drawn great attention as key targets for cancer treatment, including melanoma. In this study, we aimed to investigate the mutation status of the upstream mTOR regulator TSC1 and evaluated its correlation with the clinicopathological features...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mucous Membrane

Share to Neoplasm Staging

Share to Phosphoproteins

Share to TOR Serine-Threonine Kinases

Share to Tuberous Sclerosis Complex 1 Protein

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 29185092
DOI: 10.1007/s00432-017-2550-z

Genes

TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of TSC1 mutation spectrum in mucosal melanoma.PMID 29185092Read ↗

Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review.Semantic proximity Read ↗

RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma.Semantic proximity Read ↗

The mutational landscape of mucosal melanoma.Semantic proximity Read ↗

Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors.Semantic proximity Read ↗

Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness.Semantic proximity Read ↗

Molecular and immunohistochemical comparison between primary gastrointestinal mucosal melanomas and atypical gastrointestinal stromal tumors.Semantic proximity Read ↗

Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors.Semantic proximity Read ↗

Noncutaneous Melanomas: A Single-Center Analysis.Semantic proximity Read ↗

Sinonasal mucosal melanoma: Molecular profile and therapeutic implications from a series of 32 cases.Semantic proximity Read ↗

Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations.Semantic proximity Read ↗

Mucosal melanoma: clinical, histological and c-kit gene mutational profile of 86 French cases.Semantic proximity Read ↗

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.