Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing: results of the RING observational trial.

doi:10.1002/1878-0261.12832

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing: results of the RING observational trial.

Molecular oncology - 1 Jan 2021

Romero Atocha, Jantus-Lewintre Eloisa, García-Peláez Beatriz, Royuela Ana, Insa Amelia, Cruz Patricia, Collazo Ana, Pérez Altozano Javier, Vidal Oscar Juan, Diz Pilar, Cobo Manuel, Hernández Berta, Vázquez Estevez Sergio, Benítez Gretel, Guirado Maria, Majem Margarita, Bernabé Reyes, Ortega Ana Laura, Blasco Ana, Bosch-Barrera Joaquim, Jurado Jose M, García González Jorge, Viteri Santiago, Garcia Giron Carlos, Massutí Bartomeu, Lopez Martín Ana, Rodriguez-Festa Alejandro, Calabuig-Fariñas Silvia, Molina-Vila Miguel Ángel, Provencio Mariano

Abstract excerpt

Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, and two FDA-approved methods were compared using 72...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to DNA, Neoplasm

Share to ErbB Receptors

Share to High-Throughput Nucleotide Sequencing

Share to Predictive Value of Tests

Share to Sensitivity and Specificity

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 33107189
DOI: 10.1002/1878-0261.12832
PMCID: PMC7782072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing: results of the RING observational trial.PMID 33107189Read ↗

Comparison of cross-platform technologies for EGFR T790M testing in patients with non-small cell lung cancerSemantic proximity Read ↗

CONCORDANCE: A real-world evidence study to evaluate the concordance of detecting epidermal growth factor receptor (EGFR) mutation by circulating tumor DNA* versus tissue biopsy in patients with metastatic non-small cell lung cancer.Semantic proximity Read ↗

Detection of EGFR mutations in liquid biopsy samples using allele-specific quantitative PCR: A comparative real-world evaluation of two popular diagnostic systems.Semantic proximity Read ↗

A multicenter blinded study evaluating EGFR and KRAS mutation testing methods in the clinical non-small cell lung cancer setting--IFCT/ERMETIC2 Project Part 1: Comparison of testing methods in 20 French molecular genetic National Cancer Institute platforms.Semantic proximity Read ↗

The detection of EGFR mutation status in plasma is reproducible and can dynamically predict the efficacy of EGFR‐TKISemantic proximity Read ↗

A comparative study of EGFR oncogenic mutations in matching tissue and plasma samples from patients with advanced non-small cell lung carcinoma.Semantic proximity Read ↗

Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe.Semantic proximity Read ↗

FACILITATE: A real-world, multicenter, prospective study investigating the utility of a rapid, fully automated real-time PCR assay versus local reference methods for detecting epidermal growth factor receptor variants in NSCLC.Semantic proximity Read ↗

Consistency and reproducibility of next‐generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimensSemantic proximity Read ↗

Rapid EGFR Mutation Detection Using the Idylla Platform: Single-Institution Experience of 1200 Cases Analyzed by an In-House Developed Pipeline and Comparison with Concurrent Next-Generation Sequencing Results.Semantic proximity Read ↗

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Efficacy of liquid biopsy for disease monitoring and early prediction of tumor progression in EGFR mutation-positive non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.