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Article

Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.

Aging - 1 Feb 2016

Moiseeva Olga, Lopes-Paciencia Stéphane, Huot Geneviève, Lessard Frédéric, Ferbeyre Gerardo

Abstract excerpt

Mutants of lamin A cause diseases including the Hutchinson-Gilford progeria syndrome (HGPS) characterized by premature aging. Lamin A undergoes a series of processing reactions, including farnesylation and proteolytic cleavage of the farnesylated C-terminal domain. The role of cleavage is unknown but mutations that affect this reaction lead to progeria. Here we show that interphase serine 22 phosphorylation of...

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Identifiers

PMID: 26922519
DOI: 10.18632/aging.100903
PMCID: PMC4789588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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