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Article

A genetically mediated bias in decision making driven by failure of amygdala control.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 May 2009

Roiser Jonathan P, de Martino Benedetto, Tan Geoffrey C Y, Kumaran Dharshan, Seymour Ben, Wood Nicholas W, Dolan Raymond J

Abstract excerpt

Genetic variation at the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with altered amygdala reactivity and lack of prefrontal regulatory control. Similar regions mediate decision-making biases driven by contextual cues and ambiguity, for example the "framing effect." We hypothesized that individuals hemozygous for the short (s) allele at the 5-HTTLPR would be more susceptible to...

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Identifiers

PMID: 19420264
DOI: 10.1523/JNEUROSCI.0407-09.2009
PMCID: PMC2686091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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