Article
A mirror code for protein-cholesterol interactions in the two leaflets of biological membranes.
Scientific reports - 26 Feb 2016
Fantini Jacques, Di Scala Coralie, Evans Luke S, Williamson Philip T F, Barrantes Francisco J
Abstract excerpt
Cholesterol controls the activity of a wide range of membrane receptors through specific interactions and identifying cholesterol recognition motifs is therefore critical for understanding signaling receptor function. The membrane-spanning domains of the paradigm neurotransmitter receptor for acetylcholine (AChR) display a series of cholesterol consensus domains (referred to as "CARC"). Here we use a combination...
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