Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.

doi:10.1038/srep05296

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Article

Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.

Scientific reports - 13 Jun 2014

Wagner Robert, Li Jia, Kenar Erhan, Kohlbacher Oliver, Machicao Fausto, Häring Hans-Ulrich, Fritsche Andreas, Xu Guowang, Lehmann Rainer

Abstract excerpt

An important role of the type 2 diabetes risk variant rs7903146 in TCF7L2 in metabolic actions of various tissues, in particular of the liver, has recently been demonstrated by functional animal studies. Accordingly, the TT diabetes risk allele may lead to currently unknown alterations in human. Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during...

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PMID: 24925104
DOI: 10.1038/srep05296
PMCID: PMC4055885

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Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.PMID 24925104Read ↗

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