Article
Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.
Scientific reports - 13 Jun 2014
Wagner Robert, Li Jia, Kenar Erhan, Kohlbacher Oliver, Machicao Fausto, Häring Hans-Ulrich, Fritsche Andreas, Xu Guowang, Lehmann Rainer
Abstract excerpt
An important role of the type 2 diabetes risk variant rs7903146 in TCF7L2 in metabolic actions of various tissues, in particular of the liver, has recently been demonstrated by functional animal studies. Accordingly, the TT diabetes risk allele may lead to currently unknown alterations in human....
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