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Article

AIRE is not essential for the induction of human tolerogenic dendritic cells.

Autoimmunity - 1 Jun 2016

Crossland Katherine L, Abinun Mario, Arkwright Peter D, Cheetham Timothy D, Pearce Simon H, Hilkens Catharien M U, Lilic Desa

Abstract excerpt

Loss-of-function mutations of the Autoimmune Regulator (AIRE) gene results in organ-specific autoimmunity and disease Autoimmune Polyendocrinopathy type 1 (APS1)/Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). The AIRE protein is crucial in the induction of central tolerance, promoting ectopic expression of tissue-specific antigens in medullary thymic epithelial cells and enabling removal...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26912174
DOI: 10.3109/08916934.2016.1148692

Genes

AIRE
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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