Article
Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011
Pomié Céline, Vicente Rita, Vuddamalay Yirajen, Lundgren Brita Ardesjö, van der Hoek Mark, Enault Geneviève, Kagan Jérémy, Fazilleau Nicolas, Scott Hamish S, Romagnoli Paola, van Meerwijk Joost P M
Abstract excerpt
Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contributes to induction of immunological tolerance to self-antigens. Data from experimental mouse models...
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