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Article

Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.

The American journal of pathology - 1 Mar 2010

Poliani Pietro Luigi, Kisand Kai, Marrella Veronica, Ravanini Maria, Notarangelo Luigi Daniele, Villa Anna, Peterson Pärt, Facchetti Fabio

Abstract excerpt

Autoimmune regulator (AIRE) modulates the expression of tissue-restricted antigens (TSAs) and promotes central tolerance in the thymus. However, few autoreactive T cells escape negative selection and reach the periphery, where peripheral tolerance is required to avoid autoimmunity. Murine lymph nodes (LNs) have been shown to contain "stromal" cells expressing AIRE and TSAs. Here we report the occurrence of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20093495
DOI: 10.2353/ajpath.2010.090956
PMCID: PMC2832133

Genes

AIRE
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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