Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes.

Environmental health : a global access science source - 24 Feb 2016

Eze Ikenna C, Imboden Medea, Kumar Ashish, Adam Martin, von Eckardstein Arnold, Stolz Daiana, Gerbase Margaret W, Künzli Nino, Turk Alexander, Schindler Christian, Kronenberg Florian, Probst-Hensch Nicole

Abstract excerpt

BACKGROUND: Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine interleukin-6 may impact on glucose homeostasis. Recent meta-analyses showed the common polymorphisms, IL6 -572G > C and IL6 -174G > C to be associated with T2D risk. These IL6 variants also influence circulatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Air Pollutants
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Environmental Exposure

Share to Interleukin-6

Share to Models, Theoretical

Share to Particulate Matter

Share to Switzerland

Source

Open in PubMed Open full text

Identifiers

PMID: 26911440
DOI: 10.1186/s12940-016-0120-5
PMCID: PMC4765217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes.PMID 26911440Read ↗

Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.Semantic proximity Read ↗

Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study.Semantic proximity Read ↗

Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability.Semantic proximity Read ↗

Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.Semantic proximity Read ↗

<i>IL6</i> Gene Promoter Polymorphisms and Type 2 DiabetesSemantic proximity Read ↗

Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms.Semantic proximity Read ↗

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.Semantic proximity Read ↗

IL-6 polymorphisms: a useful genetic tool for inflammation research?Semantic proximity Read ↗

Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes.Semantic proximity Read ↗

Genetics of type 2 diabetes: impact of interleukin-6 gene variants.Semantic proximity Read ↗

Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.Semantic proximity Read ↗

A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.