Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.

doi:10.1038/jhg.2016.4

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Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.

Journal of human genetics - 1 Jun 2016

Mannan Ashraf U, Singh Jaya, Lakshmikeshava Ravikiran, Thota Nishita, Singh Suhasini, Sowmya T S, Mishra Avshesh, Sinha Aditi, Deshwal Shivani, Soni Megha R, Chandrasekar Anbukayalvizhi, Ramesh Bhargavi, Ramamurthy Bharat, Padhi Shila, Manek Payal, Ramalingam Ravi, Kapoor Suman, Ghosh Mithua, Sankaran Satish, Ghosh Arunabha, Veeramachaneni Vamsi, Ramamoorthy Preveen, Hariharan Ramesh, Subramanian Kalyanasundaram

Abstract excerpt

Breast and/or ovarian cancer (BOC) are among the most frequently diagnosed forms of hereditary cancers and leading cause of death in India. This emphasizes on the need for a cost-effective method for early detection of these cancers. We sequenced 141 unrelated patients and families with BOC using the TruSight Cancer panel, which includes 13 genes strongly associated with risk of inherited BOC. Multi-gene...

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PMID: 26911350
DOI: 10.1038/jhg.2016.4

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