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Recent Advances in Genetic Testing and Clinical Management of Hereditary Breast and Ovarian Cancer (HBOC) in India.

Cancer medicine - 1 Jul 2026

Sherigar Prathika, Kedlaya Herga Srikrishna, Pai Ananth, Mailankody Sharada, Udupa Karthik S

Abstract excerpt

BACKGROUND: Hereditary breast and ovarian cancer (HBOC) syndromes, responsible for 5%-10% of all breast and ovarian cancers in the general population, are largely associated with pathogenic variants of the BRCA1 and BRCA2 genes. Yet, the role of other cancer susceptibility genes highlights the genetic etiology of HBOC as complex, thus requiring thorough investigation beyond these main mutations, highlighting a...

Topics

Humans
Female
India
Genetic Testing
Hereditary Breast and Ovarian Cancer Syndrome
Genetic Predisposition to Disease
Genetic Counseling
Mutation
Disease Management
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

BRCA2 Protein

BRCA1 Protein

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Open in PubMed Open full text

Identifiers

PMID: 42499015
DOI: 10.1002/cam4.71497
PMCID: PMC13400834

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Recent Advances in Genetic Testing and Clinical Management of Hereditary Breast and Ovarian Cancer (HBOC) in India.PMID 42499015Read ↗

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Screening of over 1000 Indian patients with breast and/or ovarian cancer with a multi-gene panel: prevalence of BRCA1/2 and non-BRCA mutations.Semantic proximity Read ↗

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