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Article

Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome.

Human molecular genetics - 1 Apr 2016

Johansson Åsa, Eriksson Niclas, Lindholm Daniel, Varenhorst Christoph, James Stefan, Syvänen Ann-Christine, Axelsson Tomas, Siegbahn Agneta, Barratt Bryan J, Becker Richard C, Himmelmann Anders, Katus Hugo A, Steg Philippe Gabriel, Storey Robert F, Wallentin Lars

Abstract excerpt

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a strong predictor of mortality in coronary artery disease and is widely employed as a prognostic biomarker. However, a causal relationship between NT-proBNP and clinical endpoints has not been established. We have performed a genome-wide association and Mendelian randomization study of NT-proBNP. We used a discovery set of 3740 patients from the PLATelet...

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Identifiers

PMID: 26908625
DOI: 10.1093/hmg/ddw012

Genes

NPPB
GALNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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