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Article

Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.

Biochimica et biophysica acta - 1 Jul 2016

Sottas Valentin, Abriel Hugues

Abstract excerpt

During the past two decades, many pathological genetic variants in SCN5A, the gene encoding the pore-forming subunit of the cardiac (monomeric) sodium channel Na(v)1.5, have been described. Negative dominance is a classical genetic concept involving a "poison" mutant peptide that negatively interferes with the co-expressed wild-type protein, thus reducing its cellular function. This phenomenon has been described...

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Identifiers

PMID: 26907222
DOI: 10.1016/j.bbamcr.2016.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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