Article
Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome.
Pacing and clinical electrophysiology : PACE - 1 Mar 2010
Hu Dan, Barajas-Martinez Hector, Nesterenko Vladislav V, Pfeiffer Ryan, Guerchicoff Alejandra, Cordeiro Jonathan M, Curtis Anne B, Pollevick Guido D, Wu Yuesheng, Burashnikov Elena, Antzelevitch Charles
Abstract excerpt
BACKGROUND: Inherited loss of function mutations in SCN5A have been linked to overlapping syndromes including cardiac conduction disease and Brugada syndrome (BrS). The mechanisms responsible for the development of one without the other are poorly understood. METHODS: Direct sequencing was perfor...
Topics
- Adolescent
- Alleles
- Analysis of Variance
- Bradycardia
- Brugada Syndrome
- Calcium Channels, L-Type
- Electrophysiologic Techniques, Cardiac
- Female
- Heart Block
- Heart Conduction System