Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bioinformatics Insights on the Physicochemical Properties of SCN5A Mutant Proteins Associated with the Brugada Syndrome.

Current medicinal chemistry - 1 Jan 2023

Polanco Carlos, Márquez Manlio F, Uversky Vladimir N, Lemus Enrique H, Huberman Alberto, Buhse Thomas, Castro Martha R

Abstract excerpt

BACKGROUND: The Brugada syndrome (BrS) is a heart rhythm condition that is commonly associated with a strong predisposition for sudden cardiac death. Malignant ventricular arrhythmias could occur secondary to the dysfunction of the cardiac sodium voltage-gated Na(v)1.5 channel (SCN5A). OBJECTIVE: This study aimed to perform a multiparametric computational analysis of the physicochemical properties of SCN5A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brugada Syndrome
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrocardiography

Share to Genetic Predisposition to Disease

Share to Mutant Proteins

Share to Mutation

Share to NAV1.5 Voltage-Gated Sodium Channel

Source

Identifiers

PMID: 36453498
DOI: 10.2174/0929867330666221130112650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bioinformatics Insights on the Physicochemical Properties of SCN5A Mutant Proteins Associated with the Brugada Syndrome.PMID 36453498Read ↗

Novel SCN5A variants identified in a group of Iranian Brugada syndrome patients.Semantic proximity Read ↗

Utilizing multiple in silico analyses to identify putative causal SCN5A variants in Brugada syndrome.Semantic proximity Read ↗

Challenges in Brugada Syndrome Stratification: Investigating SCN5A Mutation Localization and Clinical Phenotypes.Semantic proximity Read ↗

Unravelling Novel SCN5A Mutations Linked to Brugada Syndrome: Functional, Structural, and Genetic Insights.Semantic proximity Read ↗

Functional Characterization of Two Novel Mutations in SCN5A Associated with Brugada Syndrome Identified in Italian Patients.Semantic proximity Read ↗

In silico validation revealed the role of SCN5A mutations and their genotype-phenotype correlations in Brugada syndrome.Semantic proximity Read ↗

The SCN5A Gene Is a Predictor of Phenotype Severity in Brugada Syndrome: A Comprehensive Literature Review.Semantic proximity Read ↗

Genetic biomarkers in Brugada syndrome.Semantic proximity Read ↗

Brugada Syndrome Caused by Sodium Channel Dysfunction Associated with a SCN1B Variant A197V.Semantic proximity Read ↗

Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity.Semantic proximity Read ↗

Mapping Structural Distribution and Gating-Property Impacts of Disease-Associated Missense Mutations in Voltage-Gated Sodium ChannelsSemantic proximity Read ↗

Single-cell transcriptomics trajectory and molecular convergence of clinically relevant mutations in Brugada syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.