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Article

Phenotypic Severity of SCN5A-Related Bradycardia Is Independent of Dominant-Negative and Coupled Gating Effects.

Circulation. Arrhythmia and electrophysiology - 1 Feb 2026

Tano Ayami, Kato Koichi, Yamauchi Kohei, Jinzai Hideyuki, Iguchi Takafumi, Toyoda Futoshi, Baba Yuichi, Kubo Toru, Ohno Seiko, Makiyama Takeru, Nakagawa Yoshihisa, Horie Minoru

Abstract excerpt

BACKGROUND: Pathogenic SCN5A variants are associated with inherited arrhythmias such as long-QT syndrome, Brugada syndrome, and sick sinus syndrome. While Nav1.5, an α-subunit of the cardiac sodium channel encoded by SCN5A, has been considered to function as a monomer, recent studies reveal that a reduction of sodium current in wild-type Nav1.5 can be caused by dimerization with loss-of-function mutated Nav1.5...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41582807
DOI: 10.1161/CIRCEP.125.014270
PMCID: PMC12911491

Genes

SCN5A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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