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Article

PAQR3 enhances Twist1 degradation to suppress epithelial–mesenchymal transition and metastasis of gastric cancer cells

10 Feb 2016

Abstract excerpt

Twist1 is an essential transcription factor required to initiate epithelial-mesenchymal transition (EMT) and promote tumor metastasis. PAQR3 is a newly found tumor suppressor that is frequently downregulated in many types of human cancers. Downregulation of PAQR3 is associated with accelerated metastasis and poor prognosis of the patients with gastric cancers. In this study, we demonstrate that PAQR3 is actively...

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PMID: 26905590
DOI: 10.1093/carcin/bgw013

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