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Article

Regulating retrotransposon activity through the use of alternative transcription start sites.

EMBO reports - 1 May 2016

Persson Jenna, Steglich Babett, Smialowska Agata, Boyd Mette, Bornholdt Jette, Andersson Robin, Schurra Catherine, Arcangioli Benoit, Sandelin Albin, Nielsen Olaf, Ekwall Karl

Abstract excerpt

Retrotransposons, the ancestors of retroviruses, have the potential for gene disruption and genomic takeover if not kept in check. Paradoxically, although host cells repress these elements by multiple mechanisms, they are transcribed and are even activated under stress conditions. Here, we describe a new mechanism of retrotransposon regulation through transcription start site (TSS) selection by altered nucleosome...

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Identifiers

PMID: 26902262
DOI: 10.15252/embr.201541866
PMCID: PMC5341516

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Source receipt: pubmed, retrieved 7 Sept 2026.

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