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Article

Multiplex PCR and Next Generation Sequencing for the Non-Invasive Detection of Bladder Cancer.

PloS one - 1 Jan 2016

Ward Douglas G, Baxter Laura, Gordon Naheema S, Ott Sascha, Savage Richard S, Beggs Andrew D, James Jonathan D, Lickiss Jennifer, Green Shaun, Wallis Yvonne, Wei Wenbin, James Nicholas D, Zeegers Maurice P, Cheng K K, Mathews Glenn M, Patel Prashant, Griffiths Michael, Bryan Richard T

Abstract excerpt

BACKGROUND: Highly sensitive and specific urine-based tests to detect either primary or recurrent bladder cancer have proved elusive to date. Our ever increasing knowledge of the genomic aberrations in bladder cancer should enable the development of such tests based on urinary DNA. METHODS: DNA was extracted from urine cell pellets and PCR used to amplify the regions of the TERT promoter and coding regions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 26901314
DOI: 10.1371/journal.pone.0149756
PMCID: PMC4762704

Genes

FGFR3
TERT
HRAS
RXRA

Provenance

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