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Article

Novel method for detecting frequent TERT promoter hot spot mutations in bladder cancer samples.

Clinical and experimental medicine - 14 Aug 2024

Kovács Ákos, Sükösd Farkas, Kuthi Levente, Boros Imre M, Vedelek Balázs

Abstract excerpt

Telomerase reverse transcriptase promoter (TERTp) mutations are frequently targeted tumor markers, however, they reside in regions with high GC content, which poses challenges when examined with simple molecular techniques or even with next-generation sequencing (NGS). In bladder cancer (BC), TERTp mutations are particularly frequent, however, none of the available tools have demonstrated efficacy in detecting...

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Share to Biomarkers, Tumor
Share to Cell Line, Tumor
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

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Share to Urinary Bladder Neoplasms

Source

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Identifiers

PMID: 39141194
DOI: 10.1007/s10238-024-01464-3
PMCID: PMC11324672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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