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Article

Mutation R273H confers p53 a stimulating effect on the IGF-1R-AKT pathway via miR-30a suppression in breast cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2016

Guo Fangdong, Chen Hongshen, Chang Jian, Zhang Lin

Abstract excerpt

p53 is the most highly mutated tumor suppressor in human malignancies. A wide array of p53 mutations has been revealed to play pivotal roles during cancer progression, which abolish anti-tumor functions of wild type p53 but also elicit tumorigenic effects by activating a diverse subset of downstream molecules. R273H mutation of p53 has been closely implicated in human cancer. Here we report miR-30a as a novel...

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Identifiers

PMID: 26898459
DOI: 10.1016/j.biopha.2016.01.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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